1. In EndNote, select Edit → Preferences
2. Make desired changes
3. Select OK
This video by EndNote goes over some changes you may like to make to your EndNote library. The main topics include selecting a font that can display CJK characters, linking to your EndNote Web account (1:25), enabling the "find full text" feature (2:00) and setting the preference for what EndNote does on startup (3:33).
More about Find Full Text
In the Find Full Text section of the Preferences menu, copy and paste these URL's:
OpenURL Path: http://sfxhosted.
URL (UPDATED AS OF 3/25/2015):